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Our findings suggest that the accumulation of c9,t11 CLA-PC/LPC in neuronal membranes suppresses the production of neurotoxic Aβ in neurons. The individual contents of the major fatty acids, especially cis-9, trans-11 CLA in cows of the same lactation were found variable in experiment 1. Thus, in neurons treated with c9,t11 CLA, reduced colocalization of APP with BACE1 in late endosomes may decrease APP cleavage by BACE1 and subsequent Aβ generation. Incorporation of phospholipids containing c9,t11 CLA, but not t10,c12 CLA, into the membrane may affect the localization of some membrane-associated proteins in intracellular membrane compartments. The level of CLA-containing phosphatidylcholine (CLA-PC) increased dramatically in neurons incubated with CLA. Localization of BACE1 and APP in early endosomes increased in neurons treated with c9,t11 CLA concomitantly, the localization of both proteins was reduced in late endosomes, the predominant site of APP cleavage by BACE1. BACE1 and γ-secretase activities were not directly affected by c9,t11 CLA. CLA treatment did not affect the level of β-site APP-cleaving enzyme 1 (BACE1), a component of active γ-secretase complex presenilin 1 amino-terminal fragment, or Aβ protein precursor (APP) in cultured neurons. We found that c9,t11 CLA significantly suppressed the generation of Aβ in mouse neurons. However, the effect of CLA on the generation of neurotoxic amyloid-β (Aβ) protein remains unclear. USNs CLA provides the Cis 9, Trans 11 and Trans 10, Cis 12 isomers in a 50:50 ratio, as recommended for optimal efficacy.
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But the human body is not capable of producing CLA, therefore. Two common conjugated linoleic acids (LAs), cis-9, trans-11 CLA (c9,t11 CLA) and trans-10, cis-12 CLA (t10,c12 CLA), exert various biological activities. The most well-known CLA isomers that are most commonly found in foods are 11-trans 9-cis.